BENEFITSDedicated to Providing Quality Laboratory Services

Analytical Projects

Trust the experts at Novalab to carry out difficult projects.

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Strict Quality Practices

Spinprot equipped to support rigorous quality standards.

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Customized Solutions

We develop customized protocols, methods.

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Advanced Instruments

Our teams of scientists use a wide range of instruments.

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PROTEINS

SpinProt has a complete recombinant protein express and production platform and experience on the production of prteins in bacteria, yeast and mammalian cells. Please contact us to learn more about how we can fulfill your needs.

Recombinant proteins processes:

Expression vector design and costruction (gene sythesis, codon optimization)
Expression screening and optimization
Protein expression in:

bacteria
yeast
mammalian cells

Small-scale eproduction in incubator using diiferent size culture flasks
Bioreactor-based production (20 L)
Protein modifications, tagging, labelling,
Protein optimization – solubility, folding, stability
Protein purification:

affinity
SEC
ion exchange

Providing proteins with high-purity and low-endotoxin according to customers demands.
Protein analysis and confirmation

We offer one-stop solution from sequence to final product delivery.

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APTAMERS

Aptamers (synthetic antibodies) are stable DNA or RNA ligands that bind with high affinity and specificity to target antigens such as small molecules, peptides, proteins, cells, and tissues.

SpinProt offers a complete DNA aptamer selection service. Because of the nature of te service a quotation is established based on discussions with the customer. The service includes:

Library screening – selection. After several selection rounds, potential interacting candidates are selected.
Sequencing. Sequences of potential candidates are analyzed by NGS sequencing and bioinformatic methods.
Characterization. Finding the best candidates
Binding study. We test each of the selected candidates for binding against your target. We share these results with you to decide which candidates you want made.
Maturation. To increase the binding affinity or improve the functionality, the individualcaptamer can be shortened and/or chemically modified, single or multi-base substitution can be introduced.

Contact us with your proposal or let us know what your needs are. We will help you to draft your project.

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MICROBIAL BIOMASS PROUTION

SpinProt has extensive experience in manufacturing microbial biomass and offers dedicated services for microbial fermentation of live microorganisms.

Servicess include:

Strain selection and optimization.
Fermentation process optimization
Biomass separation
Cell disruption

At SpinProt for the manufacturing we use two fermentation models, e.g. batch, fed-batch.

The end result is cell pellet. This service can be complemented with SpinProt’ other services, including: lyophilization and packing.

SpinProt offers bioproduction of different chrmicals e.g. succinic acid, chialuronic acid.

We can metaboliclly engineere microorganisms for the bioproduction of specific chemicals or increased its production. Organism Engineering for the Bioproduction is done using Lambda Red recombineering.

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FLUIDIZATION

A major challenge for manufacturers is to formulate an oil in such a way as to make it usable in consumable products. In general oil has poor water solubility and low bioavailability. The low bioavailability of oil ingridients can be overcome by formulating the products into nano-emulsions or encapsulations. Using this nano-formulations allows increased bioavailability of oil ingridients and thus the reduce dosage. Increasing stability of the formulation produce a longer self-life. The fluidizer processor technology is the only way that can create nano-sized emulsions or encapsulations (liposomes) in reprducible manner. Fluidizer technology also guarantees scale-up and reproducibility of manufacturing products. The resulting unique formulations will differentiate your products with improved shelf life, stability, and effectiveness.

A good example is CBD, one of the two ingredients of cannabis oil. CBD offers a wide range of proven medical benefits such as anti-inflammatory, anti-oxidant, anti-anxiety, etc. Direct oral administration of raw or un-ncapsulated cannabis oil provides low bioavailability of only 6-20%. The bioavailability can be increased to 50-75% through nano-formulations. For who want improved CBD fluidizer technology is a scalable solution with the highest efficiency.

SpinProt offers a fluidization services.

In the process he aqueous phase (water and surfactant) is mixed with an oil phase. This mixture is then passed through the Microfluidizer processor. The process can be optimized by adjusting process pressure, number of passes, temperature.

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LYOPHILIZATION

The freeze drying process is important in sample preparation and for the preservation and storage of biotechnological.

The nondestructive nature of this process has been demonstrated by the retention of viability in freeze dried microorganisms.

Spinprot has the laboratory equipment, laboratory and industrial scale lyophilizers, to aid in the development of optimal formulations and lyophilization cycles for your product.

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Our Expertise

PROTEINS

SpinProt has a complete recombinant protein express and production platform and experience on the production of prteins in bacteria, yeast and mammalian cells. Please contact us to learn more about how we can fulfill your needs.

APTAMERS

Aptamers (synthetic antibodies) are stable DNA or RNA ligands that bind with high affinity and specificity to target antigens such as small molecules, peptides, proteins, cells, and tissues. SpinProt offers a complete DNA aptamer selection service.

BIOPRODUCTION

We can metaboliclly engineere microorganisms for the bioproduction of specific chemicals or increased its production. Organism Engineering for the Bioproduction is done using Lambda Red recombineering.

FLUIDIZATION

In the process he aqueous phase (water and surfactant) is mixed with an oil phase. This mixture is then passed through the Microfluidizer processor. The process can be optimized by adjusting process pressure, number of passes, temperature.

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